A new paper on “Label-free nonlinear microscopy probes cellular metabolism and myelin dynamics in live tissue” is published in Communications Biology, thanks to an exciting collaboration between the Laboratoire d'Optique et Biosciences (LOB) at Institut Polytechnique de Paris and the Institut du Cerveau – Paris Brain Institute
Our label-free multimodal imaging approach combines THG myelin imaging, NAD(P)H FLIM, and advanced automated analysis to simultaneously quantify myelin architecture and cellular metabolism in living brain tissue, revealing cell-specific metabolic signatures and changes during demyelination.
Bahar Asadipour, Josephine Morizet, Remi Ronzano,Xingjian Zhang, Marie-Stephane Aigrot, Pierre Mahou, Xavier Solinas, Minh Son Phan, Anatole Chessel, Bruno Stankoff, Anne Desmazieres, Emmanuel Beaurepaire & Chiara Stringari
Communications Biology volume 8, Article number: 1811 (2025)
https://www.nature.com/articles/s42003-025-09192-4